Does medical cannabis relieve fibromyalgia pain?

Medical cannabis may reduce fibromyalgia pain for some people. Evidence is limited. No cannabis product is FDA-approved for fibromyalgia. Effects vary.

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What research shows

A 2018 Cochrane review of chronic pain found cannabis-based medicines gave 30% or more pain relief to about 10% more people than placebo. For fibromyalgia, studies are smaller. A 2021 review in the Journal of Clinical Medicine looked at 11 studies. It found THC and CBD reduced pain in some patients. But many studies had a high placebo response. A 2020 review in Current Rheumatology Reports found limited evidence.

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How cannabinoids work

THC binds to CB1 and CB2 receptors in the brain and immune system. CBD does not bind to these receptors. CBD may reduce inflammation and anxiety. Fibromyalgia involves central sensitization. Cannabinoids may change pain signaling in the central nervous system.

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Products and dosing

Medical cannabis comes in oils, capsules, tinctures, and flower. THC and CBD ratios vary. Common ratios: 1:1, 1:20, 20:1. Start low. Go slow. Typical starting dose: 1-2 mg THC per day. Increase every 2-3 days. CBD dose: 10-25 mg per day. No standard dose for fibromyalgia. A doctor can help.

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Risks and side effects

Side effects include dizziness, dry mouth, fatigue, and impaired coordination. THC can cause anxiety or paranoia. Cannabis can interact with blood thinners, opioids, and antidepressants. Long-term use may cause dependence. Do not drive after use.

Legal status in the US

Cannabis is illegal under federal law. As of 2024, 38 states allow medical cannabis. 24 states allow recreational cannabis. State laws differ. Medical cannabis requires a doctor's recommendation in most medical states.

Talk to a doctor

Fibromyalgia treatment includes exercise, cognitive behavioral therapy, and medications like duloxetine or pregabalin. Cannabis may be an add-on. Ask a doctor about risks and legal status. Do not stop prescribed medications without advice.